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Article

Association between delta-aminolevulinic acid dehydratase polymorphism and placental lead levels.

Environmental toxicology and pharmacology - 1 Jan 2016

Kayaaltı Zeliha, Sert Selda, Kaya-Akyüzlü Dilek, Söylemez Esma, Söylemezoğlu Tülin

Abstract excerpt

Lead inhibits the delta-aminolevulinic acid dehydratase (ALAD) activity and results in neurotoxic aminolevulinic acid accumulation in the blood. During pregnancy, lead in the maternal blood can easily cross the placenta. The aim of this study was to determine whether the maternal ALAD G177C polymorphism (rs1800435) was related to the placental lead levels. The study population comprised 97 blood samples taken...

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Genetic Association Studies
Genotype
Lead
Maternal Exposure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Porphobilinogen Synthase

Source

Identifiers

PMID: 26701682
DOI: 10.1016/j.etap.2015.11.017

Genes

ALAD

Variants

rs1800435

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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