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Function and Mechanism of Action of Dictyostelium Nramp1 (Slc11a1) in Bacterial Infection

9 Nov 2005

Abstract excerpt

Dictyostelium amoebae are professional phagocytes, which ingest bacteria as the principal source of food. We have cloned the Dictyostelium homologue of human natural resistance-associated membrane protein 1 (Nramp1) [solute carrier family 11 member 1 (Slc11a1)], an endo-lysosomal membrane protein that confers on macrophages resistance to infection by a variety of intracellular bacteria and protozoa. The...

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PMID: 16445684
DOI: 10.1111/j.1600-0854.2005.00356.x

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