Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Host resistance to intracellular infection: mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification.

The Journal of experimental medicine - 20 Jul 1998

Hackam D J, Rotstein O D, Zhang W, Gruenheid S, Gros P, Grinstein S

Abstract excerpt

The mechanisms underlying the survival of intracellular parasites such as mycobacteria in host macrophages remain poorly understood. In mice, mutations at the Nramp1 gene (for natural resistance-associated macrophage protein), cause susceptibility to mycobacterial infections. Nramp1 encodes an integral membrane protein that is recruited to the phagosome membrane in infected macrophages. In this study, we used...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carrier Proteins
Share to Cation Transport Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Membrane Proteins

Share to Mice, Knockout

Share to Mice, Transgenic

Share to Phagocytosis

Source

Open in PubMed Open full text

Identifiers

PMID: 9670047
DOI: 10.1084/jem.188.2.351
PMCID: PMC2212455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Host resistance to intracellular infection: mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification.PMID 9670047Read ↗

Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane.Semantic proximity Read ↗

Localisation of Nramp1 in macrophages: modulation with activation and infection.Semantic proximity Read ↗

Function and Mechanism of Action of Dictyostelium Nramp1 (Slc11a1) in Bacterial InfectionSemantic proximity Read ↗

The Nramp1 protein and its role in resistance to infection and macrophage function.Semantic proximity Read ↗

Genetic susceptibility to intracellular infections: Nramp1, macrophage function and divalent cations transport.Semantic proximity Read ↗

<i>Leishmania</i> infection triggers hepcidin-mediated proteasomal degradation of Nramp1 resulting in increased phagolysosomal iron availabilitySemantic proximity Read ↗

Mimicry of the pathogenic mycobacterium vacuole in vitro elicits the bacterial intracellular phenotype, including early-onset macrophage death.Semantic proximity Read ↗

Nramp1 locus encodes a 65 kDa interferon-γ-inducible protein in murine macrophagesSemantic proximity Read ↗

Structure and function of the natural-resistance-associated macrophage protein (Nramp1), a candidate protein for infectious and autoimmune disease susceptibility.Semantic proximity Read ↗

Nramp1 modulates iron homoeostasis in vivo and in vitro: evidence for a role in cellular iron release involving de-acidification of intracellular vesicles.Semantic proximity Read ↗

The ESAT-6/CFP-10 secretion system of Mycobacterium marinum modulates phagosome maturation.Semantic proximity Read ↗

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.