Article
Host resistance to intracellular infection: mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification.
The Journal of experimental medicine - 20 Jul 1998
Hackam D J, Rotstein O D, Zhang W, Gruenheid S, Gros P, Grinstein S
Abstract excerpt
The mechanisms underlying the survival of intracellular parasites such as mycobacteria in host macrophages remain poorly understood. In mice, mutations at the Nramp1 gene (for natural resistance-associated macrophage protein), cause susceptibility to mycobacterial infections. Nramp1 encodes an in...
Topics
- Animals
- Carrier Proteins
- Cation Transport Proteins
- Genetic Predisposition to Disease
- Macrophages, Peritoneal
- Membrane Proteins
- Mice
- Mice, Knockout
- Mice, Transgenic
- Mycobacterium bovis
- Phagocytosis
- Tuberculosis