Article
Vacuole membrane protein 1 is an endoplasmic reticulum protein required for organelle biogenesis, protein secretion, and development.
Molecular biology of the cell - 1 Aug 2008
Calvo-Garrido Javier, Carilla-Latorre Sergio, Lázaro-Diéguez Francisco, Egea Gustavo, Escalante Ricardo
Abstract excerpt
Vacuole membrane protein 1 (Vmp1) is membrane protein of unknown molecular function that has been associated with pancreatitis and cancer. The social amoeba Dictyostelium discoideum has a vmp1-related gene that we identified previously in a functional genomic study. Loss-of-function of this gene leads to a severe phenotype that compromises Dictyostelium growth and development. The expression of mammalian Vmp1 in...
Topics
- Amino Acid Sequence
- Animals
- Dictyostelium
- Endocytosis
- Endoplasmic Reticulum
- Gene Expression Regulation
- Humans
- Membrane Proteins
- Microscopy, Electron, Transmission
- Models, Biological
- Models, Genetic
- Molecular Sequence Data
- Mutation