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Article

Using the social amoeba Dictyostelium to study the functions of proteins linked to neuronal ceroid lipofuscinosis.

Journal of biomedical science - 24 Nov 2016

Huber Robert J

Abstract excerpt

Neuronal ceroid lipofuscinosis (NCL), also known as Batten disease, is a debilitating neurological disorder that affects both children and adults. Thirteen genetically distinct genes have been identified that when mutated, result in abnormal lysosomal function and an excessive accumulation of ceroid lipofuscin in neurons, as well as other cell types outside of the central nervous system. The NCL family of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27881166
DOI: 10.1186/s12929-016-0301-0
PMCID: PMC5122030

Genes

NCL
CLN3
CLN5
CLN6
CLN8
CTSD
CTSF
DNAJC5
KCTD7
MFSD8
PPT1
TPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Using the social amoeba Dictyostelium to study the functions of proteins linked to neuronal ceroid lipofuscinosis.PMID 27881166Read ↗

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