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Neisseria meningitidis expressing lgtB lipopolysaccharide targets DC-SIGN and modulates dendritic cell function.

Cellular microbiology - 1 Feb 2006

Steeghs Liana, van Vliet Sandra J, Uronen-Hansson Heli, van Mourik Andries, Engering Anneke, Sanchez-Hernandez Martha, Klein Nigel, Callard Robin, van Putten Jos P M, van der Ley Peter, van Kooyk Yvette, van de Winkel Jan G J

Abstract excerpt

Neisseria meningitidis lipopolysaccharide (LPS) has been identified as a major determinant of dendritic cell (DC) function. Here we report that one of a series of meningococcal mutants with defined truncations in the lacto-N-neotetraose outer core of the LPS exhibited unique strong adhesion and internalization properties towards DC. These properties were mediated by interaction of the...

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Identifiers

PMID: 16441441
DOI: 10.1111/j.1462-5822.2005.00623.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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