Article
Activation of human dendritic cells is modulated by components of the outer membranes of Neisseria meningitidis.
Infection and immunity - 1 Oct 2003
Al-Bader Tamara, Christodoulides Myron, Heckels John E, Holloway Judith, Semper Amanda E, Friedmann Peter S
Abstract excerpt
Neisseria meningitidis serogroup B is a major cause of life-threatening meningitis and septicemia worldwide, and no effective vaccine is available. Initiation of innate and acquired immune responses to N. meningitidis is likely to be dependent on cellular responses of dendritic cells (DC) to antigens present in the outer membrane (OM) of the meningococcus. In this study, the responses of human monocyte-derived DC...
Topics
- Antigens, CD
- B7-2 Antigen
- Base Sequence
- CD4-Positive T-Lymphocytes
- Cell Differentiation
- Cell Membrane
- Chemokines
- Cytokines
- Dendritic Cells
- Endocytosis
- Histocompatibility Antigens Class II
- Humans
- In Vitro Techniques