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Article

The amino acid sequence of Neisseria lactamica PorB surface-exposed loops influences Toll-like receptor 2-dependent cell activation.

Infection and immunity - 1 Oct 2012

Toussi Deana N, Carraway Margaretha, Wetzler Lee M, Lewis Lisa A, Liu Xiuping, Massari Paola

Abstract excerpt

Toll-like receptors (TLRs) play a major role in host mucosal and systemic defense mechanisms by recognizing a diverse array of conserved pathogen-associated molecular patterns (PAMPs). TLR2, with TLR1 and TLR6, recognizes structurally diverse bacterial products such as lipidated factors (lipoproteins and peptidoglycans) and nonlipidated proteins, i.e., bacterial porins. PorB is a pan-neisserial porin expressed...

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Source

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Identifiers

PMID: 22825445
DOI: 10.1128/IAI.00683-12
PMCID: PMC3457564

Genes

TLR2
TLR1
TLR6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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