Article
Genome-wide assessments reveal extremely high levels of polymorphism of two active families of mouse endogenous retroviral elements.
PLoS genetics - 29 Feb 2008
Zhang Ying, Maksakova Irina A, Gagnier Liane, van de Lagemaat Louie N, Mager Dixie L
Abstract excerpt
Endogenous retroviral elements (ERVs) in mice are significant genomic mutagens, causing approximately 10% of all reported spontaneous germ line mutations in laboratory strains. The majority of these mutations are due to insertions of two high copy ERV families, the IAP and ETn/MusD elements. This significant level of ongoing retrotranspositional activity suggests that inbred mice are highly variable in content of...
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