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Origins of the Endogenous and Infectious Laboratory Mouse Gammaretroviruses

26 Dec 2014

Abstract excerpt

The mouse gammaretroviruses associated with leukemogenesis are found in the classical inbred mouse strains and in house mouse subspecies as infectious exogenous viruses (XRVs) and as endogenous retroviruses (ERVs) inserted into their host genomes. There are three major mouse leukemia virus (MuLV) subgroups in laboratory mice: ecotropic, xenotropic, and polytropic. These MuLV subgroups differ in host range,...

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PMID: 25549291
DOI: 10.3390/v7010001

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