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Article

A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains.

Genome research - 1 Jan 2010

Wang Yongming, Liska Frantisek, Gosele Claudia, Sedová Lucie, Kren Vladimír, Krenová Drahomíra, Ivics Zoltán, Hubner Norbert, Izsvák Zsuzsanna

Abstract excerpt

Endogenous retroviruses (ERVs) contribute to a range of germline, as well as somatic mutations in mammals. However, autonomous retrotransposition of potentially active elements has not been demonstrated in the rat genome. We cloned an insertion that disrupted the normal splicing of the Cntrob gene that was subsequently identified as a nonautonomous, novel endogenous retrovirus of the RnERV-K8e family. The...

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Identifiers

PMID: 19887576
DOI: 10.1101/gr.100073.109
PMCID: PMC2798827

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Source receipt: pubmed, retrieved 7 Sept 2026.

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