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Article

The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene.

Nature - 25 Nov 1993

Papa F R, Hochstrasser M

Abstract excerpt

Modification of specific intracellular proteins by ubiquitin targets them for degradation. We describe a yeast enzyme, Doa4, that is integral to the degradation of ubiquitinated proteins and is required in diverse physiological processes. Doa4 appears to function late in the proteolytic pathway by cleaving ubiquitin from substrate remnants still bound to protease. The human tre-2 oncogene encodes a...

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PMID: 8247125
DOI: 10.1038/366313a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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