The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene.

doi:10.1038/366313a0

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Article

The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene.

Nature - 25 Nov 1993

Papa F R, Hochstrasser M

Abstract excerpt

Modification of specific intracellular proteins by ubiquitin targets them for degradation. We describe a yeast enzyme, Doa4, that is integral to the degradation of ubiquitinated proteins and is required in diverse physiological processes. Doa4 appears to function late in the proteolytic pathway b...

Topics

Amino Acid Sequence
Animals
Base Sequence
Endopeptidases
Endosomal Sorting Complexes Required for Transport
Fungal Proteins
Genes, Fungal
Humans
Mice
Mice, Nude
Molecular Sequence Data
Mutation
Oncogene Proteins
Oncogene Proteins, Fusion
Oncogenes
Open Reading Frames
Phenotype
Proto-Oncogene Proteins

Source

Open in PubMed

Identifiers

PMID: 8247125
DOI: 10.1038/366313a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8247125-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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