Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fluconazole treatment is effective against a Candida albicans erg3/erg3 mutant in vivo despite in vitro resistance.

Antimicrobial agents and chemotherapy - 1 Feb 2006

Miyazaki Taiga, Miyazaki Yoshitsugu, Izumikawa Koichi, Kakeya Hiroshi, Miyakoshi Shunichi, Bennett John E, Kohno Shigeru

Abstract excerpt

Candida albicans ERG3 encodes a sterol C5,6-desaturase which is essential for synthesis of ergosterol. Defective sterol C5,6 desaturation has been considered to be one of the azole resistance mechanisms in this species. However, the clinical relevance of this resistance mechanism is still unclear. In this study, we created a C. albicans erg3/erg3 mutant by the "Ura-blaster" method and confirmed the expected azole...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal Agents
Share to Candida albicans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Candidiasis

Share to Drug Resistance, Fungal

Share to Fluconazole

Share to Mice, Inbred BALB C

Share to Oxidoreductases

Share to Sterols

Source

Open in PubMed Open full text

Identifiers

PMID: 16436713
DOI: 10.1128/AAC.50.2.580-586.2006
PMCID: PMC1366932

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fluconazole treatment is effective against a Candida albicans erg3/erg3 mutant in vivo despite in vitro resistance.PMID 16436713Read ↗

Azole Resistance by Loss of Function of the Sterol Δ 5,6 -Desaturase Gene ( ERG3 ) in Candida albicans Does Not Necessarily Decrease VirulenceSemantic proximity Read ↗

Identification and characterization of four azole-resistant erg3 mutants of Candida albicans.Semantic proximity Read ↗

Loss of Upc2p-Inducible ERG3 Transcription Is Sufficient To Confer Niche-Specific Azole Resistance without Compromising Candida albicans PathogenicitySemantic proximity Read ↗

Inactivation of sterol Delta5,6-desaturase attenuates virulence in Candida albicans.Semantic proximity Read ↗

Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents.Semantic proximity Read ↗

Candida albicans sterol C-14 reductase, encoded by the ERG24 gene, as a potential antifungal target site.Semantic proximity Read ↗

Sequencing, disruption, and characterization of the Candida albicans sterol methyltransferase (ERG6) gene: drug susceptibility studies in erg6 mutants.Semantic proximity Read ↗

Loss of C-5 Sterol Desaturase Activity Results in Increased Resistance to Azole and Echinocandin Antifungals in a Clinical Isolate of Candida parapsilosis.Semantic proximity Read ↗

Cloning, sequencing, expression and allelic sequence diversity of ERG3 (C-5 sterol desaturase gene) in Candida albicans.Semantic proximity Read ↗

Up-regulation of ERG11 gene among fluconazole-resistant Candida albicans generated in vitro: is there any clinical implication?Semantic proximity Read ↗

Candida glabrata erg1 mutant with increased sensitivity to azoles and to low oxygen tension.Semantic proximity Read ↗

Squalene epoxidase encoded by ERG1 affects morphogenesis and drug susceptibilities of Candida albicans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.