Article
Plasmin modulates vascular endothelial growth factor-A-mediated angiogenesis during wound repair.
The American journal of pathology - 1 Feb 2006
Roth Detlev, Piekarek Michael, Paulsson Mats, Christ Hildegard, Bloch Wilhelm, Krieg Thomas, Davidson Jeffrey M, Eming Sabine A
Abstract excerpt
Plasmin-catalyzed cleavage of the vascular endothelial growth factor (VEGF)-A isoform VEGF165 results in loss of its carboxyl-terminal heparin-binding domain and significant loss in its bioactivity. Little is known about the in vivo significance of this process. To investigate the biological relevance of the protease sensitivity of VEGF165 in wound healing we assessed the activity of a VEGF165 mutant resistant to...
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