Article
VEGF165b, an endogenous C-terminal splice variant of VEGF, inhibits retinal neovascularization in mice.
Molecular vision - 26 May 2006
Konopatskaya O, Churchill A J, Harper S J, Bates David O, Gardiner T A
Abstract excerpt
PURPOSE: Hypoxia driven ocular angiogenesis occurs in a range of ischemic retinopathies including proliferative diabetic retinopathy and retinopathy of prematurity. These conditions are initiated and sustained by hypoxia dependent vascular endothelial growth factor (VEGF) expression in the eye. There are two families of VEGF isoforms formed by differential splicing, the pro-angiogenic VEGF family, known to...
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