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Article

Plgf-/-eNos-/- mice show defective angiogenesis associated with increased oxidative stress in response to tissue ischemia.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2006

Gigante Bruna, Morlino Giulia, Gentile Maria Teresa, Persico Maria Graziella, De Falco Sandro

Abstract excerpt

Neo-angiogenesis is a complex phenomenon modulated by the concerted action of several molecular factors. We have generated a congenic line of knockout mice carrying null mutations of both placental growth factor (PlGF) and endothelial nitric oxide synthase (eNOS), two genes that play a pivotal role in the regulation of pathological angiogenesis. In the present study, we describe the phenotype of this new...

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Share to Gene Expression Regulation, Enzymologic
Share to Ischemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neovascularization, Physiologic

Share to Nitric Oxide Synthase Type II

Share to Nitric Oxide Synthase Type III

Share to Oxidative Stress

Share to Pregnancy Proteins

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Source

Identifiers

PMID: 16608872
DOI: 10.1096/fj.05-4481fje

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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