Article
Diet suppresses glioblastoma initiation in mice by maintaining quiescence of mutation-bearing neural stem cells.
Developmental cell - 22 May 2023
Amodeo Valeria, Davies Timothy, Martinez-Segura Amalia, Clements Melanie P, Ragdale Holly Simpson, Bailey Andrew, Dos Santos Mariana Silva, MacRae James I, Mokochinski Joao, Kramer Holger, Garcia-Diaz Claudia, Gould Alex P, Marguerat Samuel, Parrinello Simona
Abstract excerpt
Glioblastoma is thought to originate from neural stem cells (NSCs) of the subventricular zone that acquire genetic alterations. In the adult brain, NSCs are largely quiescent, suggesting that deregulation of quiescence maintenance may be a prerequisite for tumor initiation. Although inactivation of the tumor suppressor p53 is a frequent event in gliomagenesis, whether or how it affects quiescent NSCs (qNSCs)...
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