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Article

DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers.

International journal of cancer - 1 Mar 2004

Kawamura Kiyoko, Bahar Rumana, Seimiya Mika, Chiyo Masako, Wada Akihiko, Okada Seiji, Hatano Masahiko, Tokuhisa Takeshi, Kimura Hideki, Watanabe Satoshi, Honda Ichiro, Sakiyama Shigeru, Tagawa Masatoshi, O-Wang Jiyang

Abstract excerpt

DNA polymerase theta (Pol theta) is a recently identified family A polymerase that contains an intrinsic helicase domain. Drosophila Pol theta mutants are hypersensitive to bifunctional DNA crosslinking agents and exhibit an elevated frequency of spontaneous chromosomal aberrations, suggesting a...

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Identifiers

PMID: 14735462
DOI: 10.1002/ijc.11666

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14735462-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers.PMID 14735462Read ↗

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Regulated over-expression of DNA polymerase beta mediates early onset cataract in mice.Semantic proximity Read ↗

DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.Semantic proximity Read ↗

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