Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers.

International journal of cancer - 1 Mar 2004

Kawamura Kiyoko, Bahar Rumana, Seimiya Mika, Chiyo Masako, Wada Akihiko, Okada Seiji, Hatano Masahiko, Tokuhisa Takeshi, Kimura Hideki, Watanabe Satoshi, Honda Ichiro, Sakiyama Shigeru, Tagawa Masatoshi, O-Wang Jiyang

Abstract excerpt

DNA polymerase theta (Pol theta) is a recently identified family A polymerase that contains an intrinsic helicase domain. Drosophila Pol theta mutants are hypersensitive to bifunctional DNA crosslinking agents and exhibit an elevated frequency of spontaneous chromosomal aberrations, suggesting a role for Pol theta in repair of DNA interstrand crosslinks and in the general maintenance of genome stability. To...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Northern
Share to Cell Separation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Colonic Neoplasms

Share to DNA-Directed DNA Polymerase

Share to Lymphocytes

Share to Lymphoid Tissue

Share to Thymus Gland

Share to Tissue Distribution

Source

Identifiers

PMID: 14735462
DOI: 10.1002/ijc.11666

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers.PMID 14735462Read ↗

Genetic determinants of cellular addiction to DNA polymerase thetaSemantic proximity Read ↗

Prognostic Significance of DNA Polymerase Theta and Its Association with Immune Infiltration in Hepatocellular CarcinomaSemantic proximity Read ↗

Role of DNA polymerase theta in tolerance of endogenous and exogenous DNA damage in mouse B cells.Semantic proximity Read ↗

Excess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cellsSemantic proximity Read ↗

POLQ Overexpression Is Associated with an Increased Somatic Mutation Load and PLK4 Overexpression in Lung AdenocarcinomaSemantic proximity Read ↗

Cloning, expression and characterization of human tissue-specific DNA polymerase lambda2.Semantic proximity Read ↗

Gastrointestinal Hyperplasia with Altered Expression of DNA Polymerase βSemantic proximity Read ↗

Analysis of specialized DNA polymerases expression in human gliomas: association with prognostic significanceSemantic proximity Read ↗

Regulated over-expression of DNA polymerase beta mediates early onset cataract in mice.Semantic proximity Read ↗

DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.Semantic proximity Read ↗

DNA polymerase expression differences in selected human tumors and cell linesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.