Article
Involvement of antibody production quantitative trait loci in the susceptibility to pristane-induced arthritis in the mouse.
Genes and immunity - 1 Jan 2006
Jensen J R, Peters L C, Borrego A, Ribeiro O G, Cabrera W H K, Starobinas N, Siqueira M, Ibañez O C M, De Franco M
Abstract excerpt
Mice obtained by bidirectional selective breeding for high (HIII) or low (LIII) antibody (Ab) production are resistant or extremely susceptible to pristane-induced arthritis (PIA), respectively. Several quantitative trait loci regulating Ab production (Ab QTL) have been mapped in these lines, which were used to investigate the influence of these Ab QTL in PIA. Parental HIII and LIII mice and their F1 and F2...
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