Article
A SOCS-1 promoter variant is associated with total serum IgE levels.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2011
Mostecki Justin, Cassel Suzanne L, Klimecki Walter T, Stern Debra A, Knisz Judit, Iwashita Sachiyo, Graves Penelope, Miller Rachel L, van Peer Maartje, Halonen Marilyn, Martinez Fernando D, Vercelli Donata, Rothman Paul B
Abstract excerpt
SOCS-1 is a critical regulator of multiple signaling pathways, including those activated by cytokines that regulate Ig H chain class switching to IgE. Analysis of mice with mutations in the SOCS-1 gene demonstrated that IgE levels increase with loss of SOCS-1 alleles. This suggested that overall SOCS-1 acts as an inhibitor of IgE expression in vivo. A genetic association study was performed in 474 children...
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