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Article

Xaf1 can cooperate with TNFalpha in the induction of apoptosis, independently of interaction with XIAP.

Molecular and cellular biochemistry - 1 Jun 2006

Xia Yan, Novak Rachel, Lewis Jennifer, Duckett Colin S, Phillips Andrew C

Abstract excerpt

XIAP-associated factor 1 (Xaf1) binds XIAP and re-localizes it to the nucleus, thus inhibiting XIAP activity and enhancing apoptosis [1]. Xaf1 expression is reduced or absent in tumor samples and cell lines suggesting it may function as a tumor suppressor [2-5]. To further study Xaf1 function we generated Xaf1 inducible cells in the osteosarcoma cell line Saos-2. Despite Xaf1 inducing apoptosis that is...

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Source

Identifiers

PMID: 16432762
DOI: 10.1007/s11010-005-9094-2

Genes

XIAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Xaf1 can cooperate with TNFalpha in the induction of apoptosis, independently of interaction with XIAP.PMID 16432762Read ↗

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XAF1 is a promising target to regulate osteoclastogenesisSemantic proximity Read ↗

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