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Article

XAF1 contributes to dengue virus‐induced apoptosis in vascular endothelial cells

3 Dec 2012

Abstract excerpt

The mechanism of vascular leakage in severe dengue infection remains unclear. Here, we used primary human umbilical vein endothelial cells (HUVECs) and the EA.hy926 cell line to study the molecular events that occur after dengue virus serotype 2 (DENV2) infection. DENV2-induced apoptosis was confirmed using nuclear staining, TUNEL assay, and electron microscopy. A genome-wide transcriptome analysis was performed...

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PMID: 23207547
DOI: 10.1096/fj.12-213967

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