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Article

c-Jun N-terminal kinase (JNK1) upregulates XIAP-associated factor 1 (XAF1) through interferon regulatory factor 1 (IRF-1) in gastrointestinal cancer.

Carcinogenesis - 1 Feb 2009

Wang Jide, Zhang Wenjing, Zhang Yusheng, Chen Ye, Zou Bing, Jiang Bo, Pang Roberta, Gu Qing, Qiao Liang, Lan Huiyao, Kung Hsiang-Fu, Wong Benjamin C Y

Abstract excerpt

BACKGROUND AND AIMS: X-linked inhibitor of apoptosis protein-associated factor 1 (XAF1) is a tumor suppressor that can sensitize cancer cell to apoptosis. Intrinsic expression of XAF1 in cancer cell is low. Our purpose is to determine the effect of c-Jun N-terminal kinase 1 (JNK1) on XAF1 expression and the putative mechanism. METHODS: XAF1 expression in gastrointestinal (GI) cancer cell line AGS and SW1116 was...

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Source

Identifiers

PMID: 19056926
DOI: 10.1093/carcin/bgn271

Genes

XAF1
TNF
XIAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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c-Jun N-terminal kinase (JNK1) upregulates XIAP-associated factor 1 (XAF1) through interferon regulatory factor 1 (IRF-1) in gastrointestinal cancer.PMID 19056926Read ↗

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