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Article

An association study of asthma and related phenotypes with polymorphisms in negative regulator molecules of the TLR signaling pathway.

Journal of human genetics - 1 Jan 2006

Nakashima Kazuko, Hirota Tomomitsu, Obara Kazuhiko, Shimizu Makiko, Jodo Aya, Kameda Makoto, Doi Satoru, Fujita Kimie, Shirakawa Taro, Enomoto Tadao, Kishi Fumio, Yoshihara Shigemi, Matsumoto Kenji, Saito Hirohisa, Suzuki Yoichi, Nakamura Yusuke, Tamari Mayumi

Abstract excerpt

Although associations between endotoxin exposure or respiratory infection and asthma have been recognized, the genetic effects in these conditions are unclear. Toll-like receptors (TLRs) play an essential role in innate host defense and in the control of adaptive immune responses. IL-1R-associated kinase-M (IRAK-M) and single immunoglobulin IL-1R-related molecule (SIGIRR) negatively regulate TLR-signaling...

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Source

Identifiers

PMID: 16432636
DOI: 10.1007/s10038-005-0358-1

Genes

SIGIRR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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