Article
Pharmacokinetics of olanzapine after single-dose oral administration of standard tablet versus normal and sublingual administration of an orally disintegrating tablet in normal volunteers.
Journal of clinical pharmacology - 1 Feb 2006
Markowitz John S, DeVane C Lindsay, Malcolm Robert J, Gefroh Holly A, Wang Jun-Sheng, Zhu Hao-Jie, Donovan Jennifer L
Abstract excerpt
Olanzapine (OLZ) is a second-generation antipsychotic agent available in 2 solid oral dosage forms, a standard oral tablet (SOT) and an orally disintegrating tablet (ODT). This study assessed the absorption of each by different routes of administration. Secondarily, the influence of P-glycoprotein (P-gp) genotype was assessed. It was hypothesized that more rapid absorption of the OLZ ODT would occur when...
Topics
- ATP Binding Cassette Transporter, Subfamily B
- Administration, Oral
- Administration, Sublingual
- Adult
- Antipsychotic Agents
- Benzodiazepines
- Chromatography, High Pressure Liquid
- Cross-Over Studies
- DNA
- Female
- Genotype
- Humans