Article
Pharmacokinetics and bioavailability comparison of generic and branded citalopram 20 mg tablets: an open-label, randomized-sequence, two-period crossover study in healthy Chinese CYP2C19 extensive metabolizers.
Clinical drug investigation - 1 Jan 2013
Jiang Tao, Rong Zhengxing, Xu Yiping, Chen Bing, Xie Yifan, Chen Congying, Lu Yang, Shen Yifeng, Li Huafang, Sun Jing, Chen Hongzhuan
Abstract excerpt
BACKGROUND: Citalopram is a selective serotonin reuptake inhibitor (SSRI) mainly prescribed to treat major depression. OBJECTIVE: The aim of this study was to compare the pharmacokinetic characteristics of a new and a branded citalopram 20 mg formulation to support the marketing authorization of the test formulation in China. METHODS: A single-dose, open-label, randomized-sequence, two-period crossover design was...
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