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Article

High throughput detection of M6P/IGF2R intronic hypermethylation and LOH in ovarian cancer.

Nucleic acids research - 1 Jan 2006

Huang Zhiqing, Wen Yaqing, Shandilya Ruby, Marks Jeffrey R, Berchuck Andrew, Murphy Susan K

Abstract excerpt

Cell surface mannose 6-phosphate/insulin-like growth factor II receptors (M6P/IGF2R) bind and target exogenous insulin-like growth factor II (IGF2) to the prelysosomes where it is degraded. Loss of heterozygosity (LOH) for M6P/IGF2R is found in cancers, with mutational inactivation of the remaining allele. We exploited the normal allele-specific differential methylation of the M6P/IGF2R intron 2 CpG island to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16432260
DOI: 10.1093/nar/gkj468
PMCID: PMC1345698

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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