Article
Genome-scale screen for DNA methylation-based detection markers for ovarian cancer.
PloS one - 1 Jan 2011
Campan Mihaela, Moffitt Melissa, Houshdaran Sahar, Shen Hui, Widschwendter Martin, Daxenbichler Günter, Long Tiffany, Marth Christian, Laird-Offringa Ite A, Press Michael F, Dubeau Louis, Siegmund Kimberly D, Wu Anna H, Groshen Susan, Chandavarkar Uma, Roman Lynda D, Berchuck Andrew, Pearce Celeste L, Laird Peter W
Abstract excerpt
BACKGROUND: The identification of sensitive biomarkers for the detection of ovarian cancer is of high clinical relevance for early detection and/or monitoring of disease recurrence. We developed a systematic multi-step biomarker discovery and verification strategy to identify candidate DNA methylation markers for the blood-based detection of ovarian cancer. METHODOLOGY/PRINCIPAL FINDINGS: We used the Illumina...
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