Article
Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 1997
Yamada T, De Souza A T, Finkelstein S, Jirtle R L
Abstract excerpt
This report shows that loss of heterozygosity at the mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) locus occurred in 5/8 (63%) dysplastic liver lesions and 11/18 (61%) hepatocellular carcinomas (HCCs) associated with the high risk factors of hepatitis virus infection and...
Topics
- Aged
- Carcinoma, Hepatocellular
- Chromosome Deletion
- Female
- Heterozygote
- Humans
- Immunohistochemistry
- Liver Neoplasms
- Male
- Middle Aged
- Mutation
- Receptor, IGF Type 2
- Risk Factors