Article
M6P/IGF2R tumor suppressor gene mutated in hepatocellular carcinomas in Japan.
Hepatology (Baltimore, Md.) - 1 May 2002
Oka Yoshihiko, Waterland Robert A, Killian J Keith, Nolan Catherine M, Jang Hong-Seok, Tohara Keiji, Sakaguchi Seigo, Yao Tsuneyoshi, Iwashita Akinori, Yata Yutaka, Takahara Terumi, Sato Shin-Ichiro, Suzuki Kazuyuki, Masuda Tomoyuki, Jirtle Randy L
Abstract excerpt
Mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) tumor suppressor- gene mutation is an early event in human hepatocellular carcinoma (HCC) formation in the United States, but its role in hepatocarcinogenesis in Japan is unclear. We therefore determined M6P/IGF2R mutation frequency in HCCs from patients who resided in the southern, central, and northern regions of Japan. Ten single nucleotide...
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