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Article

M6P/IGF2R is mutated in squamous cell carcinoma of the lung.

Oncogene - 16 Mar 2000

Kong F M, Anscher M S, Washington M K, Killian J K, Jirtle R L

Abstract excerpt

In addition to the intracellular sorting of lysosomal enzymes, the mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) plays a critical role in regulating the bioavailability of extracellular proteolytic enzymes and growth factors. It has also been shown to be mutated in a number of human cancers, and to suppress cancer cell growth. The purpose of this study was to determine if the M6P/IGF2R is...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carcinoma, Squamous Cell

Share to Loss of Heterozygosity

Share to Lung Neoplasms

Share to Receptor, IGF Type 2

Source

Identifiers

PMID: 10734317
DOI: 10.1038/sj.onc.1203437

Genes

IGF2R
IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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