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Article

M6P/IGF2R loss of heterozygosity in head and neck cancer associated with poor patient prognosis.

BMC cancer - 13 Feb 2003

Jamieson Timothy A, Brizel David M, Killian J Keith, Oka Yoshihiko, Jang Hong-Seok, Fu Xiaolong, Clough Robert W, Vollmer Robin T, Anscher Mitchell S, Jirtle Randy L

Abstract excerpt

BACKGROUND: The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) encodes for a multifunctional receptor involved in lysosomal enzyme trafficking, fetal organogenesis, cytotoxic T cell-induced apoptosis and tumor suppression. The purpose of this investigation was to determine if the M6P/IGF2R tumor suppressor gene is mutated in human head and neck cancer, and if allelic loss is associated with...

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Identifiers

PMID: 12589712
DOI: 10.1186/1471-2407-3-4
PMCID: PMC151601

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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