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Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability

16 Sept 2009

Abstract excerpt

Inositol requiring enzyme-1 (IRE1), a protein located on the endoplasmic reticulum (ER) membrane, is highly conserved from yeast to humans. This protein is activated during ER stress and induces cellular adaptive responses to the stress. In mice, IRE1alpha inactivation results in widespread developmental defects, leading to embryonic death after 12.5 days of gestation. However, the cause of this embryonic...

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PMID: 19805353
DOI: 10.1073/pnas.0903775106

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