Article
Sphingolipid biosynthesis in pathogenic fungi: identification and characterization of the 3-ketosphinganine reductase activity of Candida albicans and Aspergillus fumigatus.
Biochimica et biophysica acta - 1 Jan 2006
Fornarotto Michelle, Xiao Li, Hou Yan, Koch Keith A, Chang Edcon, O'Malley Robert M, Black Todd A, Cable Michael B, Walker Scott S
Abstract excerpt
An early step in sphingolipid biosynthesis, the reduction of 3-ketosphinganine, is catalyzed in the yeast Saccharomyces cerevisiae by Tsc10p (TSC10 (YBR265W)). We have identified orthologs of TSC10 in two clinically important fungal pathogens, Candida albicans and Aspergillus fumigatus. The translated sequences of the putative C. albicans ortholog, KSR1 (orf6.5112), and the putative A. fumigatus ortholog, ksrA,...
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