Article
The Regulatory Proteins Rtg1/3 Govern Sphingolipid Homeostasis in the Human-Associated Yeast Candida albicans.
Cell reports - 21 Jan 2020
Moreno-Velásquez Sergio D, Tint Su Hlaing, Del Olmo Toledo Valentina, Torsin Sanda, De Sonakshi, Pérez J Christian
Abstract excerpt
Integrating nutrient sensing with the synthesis of complex molecules is a central feature of metabolism. Yet the regulatory mechanisms underlying such integration are often unknown. Here, we establish that the transcription regulators Rtg1/3 are key determinants of sphingolipid homeostasis in the human fungal pathogen Candida albicans. Quantitative analysis of the C. albicans lipidome reveals Rtg1/3-dependent...
Topics
- Adult
- Candida albicans
- Cell Nucleus
- Fungal Proteins
- Gene Expression Profiling
- Gene Expression Regulation, Fungal
- Homeostasis
- Humans
- Metabolomics
- Mutation
- Neutrophils
- Phenotype
- Phosphorylation
- Proteolysis