Article
Large-Scale Analysis of Kinase Signaling in Yeast Pseudohyphal Development Identifies Regulation of Ribonucleoprotein Granules.
PLoS genetics - 1 Oct 2015
Shively Christian A, Kweon Hye Kyong, Norman Kaitlyn L, Mellacheruvu Dattatreya, Xu Tao, Sheidy Daniel T, Dobry Craig J, Sabath Ivan, Cosky Eric E P, Tran Elizabeth J, Nesvizhskii Alexey, Andrews Philip C, Kumar Anuj
Abstract excerpt
Yeast pseudohyphal filamentation is a stress-responsive growth transition relevant to processes required for virulence in pathogenic fungi. Pseudohyphal growth is controlled through a regulatory network encompassing conserved MAPK (Ste20p, Ste11p, Ste7p, Kss1p, and Fus3p), protein kinase A (Tpk2p), Elm1p, and Snf1p kinase pathways; however, the scope of these pathways is not fully understood. Here, we implemented...
Topics
- Candida albicans
- Gene Expression Regulation, Fungal
- Hyphae
- Phenotype
- Phosphorylation
- Phosphotransferases
- Ribonucleoproteins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins