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Article

Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors.

PloS one - 1 Jan 2018

Kharel Yugesh, Agah Sayeh, Huang Tao, Mendelson Anna J, Eletu Oluwafunmilayo T, Barkey-Bircann Peter, Gesualdi James, Smith Jeffrey S, Santos Webster L, Lynch Kevin R

Abstract excerpt

Successful medicinal chemistry campaigns to discover and optimize sphingosine kinase inhibitors require a robust assay for screening chemical libraries and for determining rank order potencies. Existing assays for these enzymes are laborious, expensive and/or low throughput. The toxicity of excessive levels of phosphorylated sphingoid bases for the budding yeast, Saccharomyces cerevisiae, affords an assay wherein...

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Identifiers

PMID: 29672528
DOI: 10.1371/journal.pone.0192179
PMCID: PMC5908134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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