Article
The Saccharomyces cerevisiae TSC10/YBR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2Delta mutant.
The Journal of biological chemistry - 13 Nov 1998
Beeler T, Bacikova D, Gable K, Hopkins L, Johnson C, Slife H, Dunn T
Abstract excerpt
Saccharomyces cerevisiae csg2Delta mutants accumulate the sphingolipid inositolphosphorylceramide, which renders the cells Ca2+-sensitive. Temperature-sensitive mutations that suppress the Ca2+ sensitivity of csg2Delta mutants were isolated and characterized to identify genes that encode sphingol...
Topics
- Acetyl Coenzyme A
- Alcohol Oxidoreductases
- Amino Acid Sequence
- Calcium
- Calcium-Binding Proteins
- Fungal Proteins
- Humans
- Molecular Sequence Data
- Phenotype
- Repressor Proteins
- Saccharomyces cerevisiae