Article

Functional analysis of the mouse CBP gene in the adult central nervous system

2002-01-01

Abstract excerpt

CBP (CREB-binding protein) was originally characterized as a transcriptional coactivator of CREB (cAMP response element-binding protein) which is implicated in many processes including the formation of long-term memory. CBP itself is regulated by nuclear Ca<sup>2+</sup> and Ca<sup>2+</sup>/Calmodulin kinase IV, suggesting a crucial role in synaptic plasticity. Mutations in human <i>CBP</i> gene are associated with...

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Literature Corpus work: 6e86f27b-aec8-5464-ac08-4799a16c989a
DOI: 10.21954/ou.ro.0000fd2c

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