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Article

A multivariate analysis of HIV-1 protease inhibitors and resistance induced by mutation.

Journal of chemical information and modeling - 1 Jan 2000

Almerico Anna Maria, Tutone Marco, Lauria Antonino, Diana Patrizia, Barraja Paola, Montalbano Alessandra, Cirrincione Girolamo, Dattolo Gaetano

Abstract excerpt

This paper describes the use of the multivariate statistical procedure principal component analysis as a tool to explore the inhibitory activity of classes of protease inhibitors (PIs) against HIV-1 viruses (wild type and more-frequent single mutants, V82A, V82F, and I84V) and against protease enzymes. The analysis of correlations between biological activity and molecular descriptors or similarity indexes allowed...

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Identifiers

PMID: 16426053
DOI: 10.1021/ci050139z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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