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Article

Analysis of correlated mutations in HIV-1 protease using spectral clustering.

Bioinformatics (Oxford, England) - 15 May 2008

Liu Ying, Eyal Eran, Bahar Ivet

Abstract excerpt

MOTIVATION: The ability of human immunodeficiency virus-1 (HIV-1) protease to develop mutations that confer multi-drug resistance (MDR) has been a major obstacle in designing rational therapies against HIV. Resistance is usually imparted by a cooperative mechanism that can be elucidated by a covariance analysis of sequence data. Identification of such correlated substitutions of amino acids may be obscured by...

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Identifiers

PMID: 18375964
DOI: 10.1093/bioinformatics/btn110
PMCID: PMC2373918

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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