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Article

Exploring the conformational landscapes of HIV protease structural ensembles using principal component analysis.

Proteins - 1 Sept 2018

Hassan Sameer, Srikakulam Sanjay Kumar, Chandramohan Yuvaraj, Thangam Manonanthini, Muthukumar Soundharrya, Gayathri Devi P K, Hanna Luke Elizabeth

Abstract excerpt

HIV protease, an essential enzyme for viral particle maturation, is an important drug target of HIV. Its structural conformation is a key determinant of both biological function as well as efficient binding of protease inhibitor molecules. In the present study we analyzed 471 crystal structures of HIV-1 protease to understand the conformational changes induced by mutations or binding of various ligands and...

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PMID: 30051500
DOI: 10.1002/prot.25534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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