Article
Alternative methods to analyse the impact of HIV mutations on virological response to antiviral therapy.
BMC medical research methodology - 22 Oct 2008
Wittkop Linda, Commenges Daniel, Pellegrin Isabelle, Breilh Dominique, Neau Didier, Lacoste Denis, Pellegrin Jean-Luc, Chêne Geneviève, Dabis François, Thiébaut Rodolphe
Abstract excerpt
BACKGROUND: Principal component analysis (PCA) and partial least square (PLS) regression may be useful to summarize the HIV genotypic information. Without pre-selection each mutation presented in at least one patient is considered with a different weight. We compared these two strategies with the construction of a usual genotypic score. METHODS: We used data from the ANRS-CO3 Aquitaine Cohort Zephir sub-study. We...
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