Article
APE1 genotype and risk of bladder cancer: evidence for effect modification by smoking.
International journal of cancer - 15 Jun 2006
Terry Paul D, Umbach David M, Taylor Jack A
Abstract excerpt
Apurinic/apyrimidinic (AP) sites are common mutagenic and cytotoxic DNA lesions that arise from the loss of normal bases. APE1, the major AP endonuclease of human cells, plays a central role in the repair of AP sites through both its endonuclease and phosphodiesterase activities. A common APE1 polymorphism, a T-->G transversion (Asp 148 Glu), was previously shown to be associated with risk of lung cancer, an...
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