Article
Genetic variants of XRCC1, APE1, and ADPRT genes and risk of bladder cancer.
DNA and cell biology - 1 Jun 2010
Wang Meilin, Qin Chao, Zhu Jian, Yuan Lin, Fu Guangbo, Zhang Zhengdong, Yin Changjun
Abstract excerpt
DNA damaged by exposure to exogenous and endogenous carcinogens could be removed effectively by the base excision repair pathway, in which the XRCC1, APE1, and ADPRT genes play a key role. Genetic variations in these important genes may alter repair function and contribute to cancer risk. We hypothesized that XRCC1, APE1, and ADPRT polymorphisms are associated with risk of bladder cancer. In a hospital-based...
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