Article
The single nucleotide polymorphism IVS1+309 in mouse double minute 2 does not affect risk of familial breast cancer.
Cancer research - 15 Jan 2006
Wilkening Stefan, Bermejo Justo Lorenzo, Burwinkel Barbara, Klaes Rüdiger, Bartram Claus R, Meindl Alfons, Bugert Peter, Schmutzler Rita K, Wappenschmidt Barbara, Untch Michael, Hemminki Kari, Försti Asta
Abstract excerpt
The mouse double minute 2 (MDM2) oncoprotein promotes cell survival and cell cycle progression by inhibiting the p53 tumor suppressor protein. Further, MDM2 overexpression can inhibit DNA double-strand break repair in a p53-independent manner. Recently, it was shown that a single nucleotide polymorphism (SNP) in the MDM2 promoter was associated with an accelerated tumor formation in individuals with a p53...
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