Article
Anti-P-selectin lectin-EGF domain monoclonal antibody inhibits the maturation of human immature dendritic cells.
Experimental and molecular pathology - 1 Apr 2006
Zhou Tong, Zhang Yanyun, Sun Guizhi, Zhang Yumei, Zhang Dongqing, Zhao Yapeng, Chen Nan
Abstract excerpt
Dendritic cells (DCs) are professional antigen-presenting cells with the ability to initiate primary T cell responses. While it is well known that inflammatory stimuli induce the functional maturation of immature DCs, whether adhesion molecule selectins regulate DC maturation is poorly understood. Using anti-P-selectin lectin-EGF domain monoclonal antibody (PsL-EGFmAb) that blocks the adhesion of P-, E-, and...
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