Article
Natural antibodies sustain differentiation and maturation of human dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America - 28 Sept 2004
Bayry Jagadeesh, Lacroix-Desmazes Sébastien, Donkova-Petrini Vladimira, Carbonneil Cédric, Misra Namita, Lepelletier Yves, Delignat Sandrine, Varambally Sooryanarayana, Oksenhendler Eric, Lévy Yves, Debré Marianne, Kazatchkine Michel D, Hermine Olivier, Kaveri Srini V
Abstract excerpt
The differentiation and maturation of dendritic cells (DCs) is governed by various signals in the microenvironment. Monocytes and DCs circulate in peripheral blood, which contains high levels of natural antibodies (NAbs). NAbs are germ-line-encoded and occur in the absence of deliberate immunization or microbial aggression. To assess the importance of NAbs in the milieu on DC development, we examined the status...
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