Article
Role of RNA polymerase II carboxy terminal domain phosphorylation in DNA damage response.
Journal of microbiology (Seoul, Korea) - 1 Dec 2005
Jeong Su-Jin, Kim Hye-Jin, Yang Yong-Jin, Seol Ja-Hwan, Jung Bo-Young, Han Jeong-Whan, Lee Hyang-Woo, Cho Eun-Jung
Abstract excerpt
The phosphorylation of C-terminal domain (CTD) of Rpb1p, the largest subunit of RNA polymerase II plays an important role in transcription and the coupling of various cellular events to transcription. In this study, its role in DNA damage response is closely examined in Saccharomyces cerevisiae, focusing specifically on several transcription factors that mediate or respond to the phosphorylation of the CTD....
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