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Article

Pten-mediated Gsk3β modulates the naïve pluripotency maintenance in embryonic stem cells.

Cell death & disease - 7 Feb 2020

Wang Wuming, Lu Gang, Su Xianwei, Tang Chengcheng, Li Hongjian, Xiong Zhiqiang, Leung Chi-Kwan, Wong Man-Sze, Liu Hongbin, Ma Jin-Long, Cheung Hoi-Hung, Kung Hsiang-Fu, Chen Zi-Jiang, Chan Wai-Yee

Abstract excerpt

Mouse embryonic stem cells (ESCs) are isolated from the inner cell mass of blastocysts, and they exist in different states of pluripotency-naïve and primed states. Pten is a well-known tumor suppressor. Here, we generated Pten-/- mouse ESCs with the CRISPR-Cas9 system and verified that Pten-/- ESCs maintained naïve pluripotency by blocking Gsk3β activity. Serum/LIF and 2i (MAPK and GSK3 inhibitors) conditions are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32034125
DOI: 10.1038/s41419-020-2271-0
PMCID: PMC7007436

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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